Learn About Stomach Ulcers and Treatment Options

Understanding What Stomach Ulcers Are

A stomach ulcer, also called a peptic ulcer, is a sore that develops in the lining of your stomach, small intestine, or esophagus. Think of it like a small wound that forms when the protective layer of your stomach gets damaged. Your stomach naturally produces strong acid to help break down food, but this acid is normally protected by a mucus layer that keeps it from eating through the stomach wall itself. When this protective barrier breaks down, the acid can create an open sore.

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Stomach ulcers are more common than many people realize. According to research from the National Institutes of Health, about 1 in 10 Americans will develop a stomach ulcer at some point in their lives. They can range in size from very small (like a pinhead) to quite large (over an inch across). Some people have just one ulcer, while others develop several.

There are three main types of peptic ulcers based on location. Gastric ulcers form in the stomach itself. Duodenal ulcers develop in the duodenum, which is the first part of the small intestine just below the stomach. Esophageal ulcers occur in the esophagus, the tube that carries food from your mouth to your stomach. Duodenal ulcers are the most common type, accounting for about 80 percent of all peptic ulcers.

The symptoms of stomach ulcers vary from person to person. Some people experience no symptoms at all and only discover they have an ulcer when complications develop. Others report a burning pain in the stomach area, particularly between meals or late at night. Additional symptoms may include bloating, heartburn, nausea, vomiting, dark or bloody stools, and unexplained weight loss. The pain pattern often depends on where the ulcer is located and how severe it is.

Practical Takeaway: Understanding that stomach ulcers are a common condition with specific causes helps you recognize why treatment is important. If you experience persistent stomach pain or notice blood in your vomit or stool, contacting a healthcare provider can lead to proper diagnosis and treatment.

The Main Causes of Stomach Ulcers

For many decades, doctors believed that stress and spicy food caused most stomach ulcers. This understanding changed dramatically in the 1980s when researchers discovered that a bacterium called Helicobacter pylori (H. pylori) was responsible for a large percentage of ulcers. This discovery was so significant that it earned the researchers a Nobel Prize in Physiology or Medicine in 2005.

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H. pylori is a bacterium that lives in the stomach lining and can survive in the acidic environment there. It spreads from person to person through contaminated food or water, or through saliva. According to the Centers for Disease Control and Prevention, H. pylori infections are common worldwide, affecting roughly half the global population, though rates are lower in developed countries. When H. pylori infects the stomach, it causes inflammation that weakens the protective mucus layer, allowing acid to create ulcers. About 90 percent of duodenal ulcers and 70 percent of gastric ulcers are caused by this bacterium.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the second leading cause of stomach ulcers. These medications include aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve). NSAIDs reduce pain and inflammation but can irritate and damage the stomach lining, especially when taken regularly or in high doses. People who use NSAIDs for conditions like arthritis, chronic pain, or regular headache management have higher risk of developing ulcers. The risk increases significantly for people over 65 and those taking blood thinners simultaneously.

Several other factors can contribute to ulcer development. Smoking increases stomach acid production and weakens the stomach's ability to protect itself. Alcohol irritates the stomach lining and can trigger ulcer formation. Stress, while not a direct cause, can increase stomach acid production and may worsen existing ulcers. Certain foods like spicy dishes, caffeine, and chocolate may trigger symptoms in some people, though they don't directly cause ulcers. In rare cases (less than 1 percent), ulcers result from a condition called Zollinger-Ellison syndrome, which causes the stomach to produce excessive acid.

Practical Takeaway: Knowing the primary causes of ulcers—H. pylori bacteria and NSAID use—helps you understand why your doctor will likely test for H. pylori and ask about your medication history. If you regularly take NSAIDs and develop stomach symptoms, discussing alternatives with your healthcare provider is important.

How Doctors Diagnose Stomach Ulcers

Diagnosing a stomach ulcer typically begins with a conversation between you and your healthcare provider. You'll describe your symptoms, how long you've had them, what makes them better or worse, and your medical history including medications you take. This information helps narrow down whether an ulcer is likely and guides which tests might be needed.

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Several diagnostic tests can confirm the presence of an ulcer. The upper endoscopy is the most definitive test. In this procedure, a doctor inserts a long, thin tube with a tiny camera (called an endoscope) down your throat while you're sedated. This allows the doctor to directly visualize your stomach and small intestine lining, see if ulcers are present, and take small tissue samples if needed. The procedure takes about 15 to 20 minutes, and most people go home the same day.

For testing H. pylori specifically, several options are available. The urea breath test involves drinking a special liquid containing a harmless radioactive substance. If H. pylori is present, it breaks down this substance, and the radioactive carbon is absorbed and exhaled in your breath, which is then measured. The stool antigen test detects H. pylori proteins in your feces and doesn't require any invasive procedures. Blood tests can show antibodies to H. pylori, indicating current or past infection. Sometimes doctors take tissue samples during an endoscopy to test directly for the bacteria. The accuracy of these tests ranges from 90 to 95 percent when performed correctly.

Additional imaging tests may be used in some situations. An upper gastrointestinal (GI) series uses X-rays with a contrast dye to visualize the stomach and small intestine. While less detailed than endoscopy, it can show larger ulcers and is less invasive. CT scans might be ordered if complications like perforation (a hole in the stomach wall) are suspected.

If you have concerning symptoms like difficulty swallowing, persistent vomiting, vomiting blood, or black tar-like stools, seeking medical evaluation promptly is important. These could indicate complications requiring urgent care. Don't assume stomach pain is just an ulcer—other conditions like gastritis, gallstones, or pancreatitis can cause similar symptoms.

Practical Takeaway: Getting a proper diagnosis requires seeing a healthcare provider who can order appropriate tests. The type of test recommended depends on your symptoms and medical history, so discussing your situation thoroughly with your doctor helps ensure accurate diagnosis and effective treatment planning.

Treatment Options for Stomach Ulcers

Treatment for stomach ulcers depends on the underlying cause. If H. pylori bacteria is found, your doctor will prescribe a combination of medications, typically called triple or quadruple therapy. This usually involves an acid-reducing medication plus two to three antibiotics taken together for one to two weeks. Common antibiotic combinations include amoxicillin with clarithromycin, or metronidazole with clarithromycin. After completing the antibiotic course, your doctor may test you again to confirm the H. pylori has been eliminated. Studies show that this approach successfully eradicates H. pylori in about 85 to 90 percent of cases on the first treatment attempt.

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Acid-reducing medications form the foundation of ulcer treatment regardless of cause. Proton pump inhibitors (PPIs) like omeprazole, lansoprazole, and pantoprazole are the most effective and are typically prescribed for four to eight weeks. These medications block the mechanism that produces stomach acid, allowing the ulcer to heal. H2-receptor blockers like famotidine and ranitidine reduce acid production less dramatically but are still effective and may be used when PPIs aren