Hand, foot, and mouth disease (HFMD) is a viral infection that most commonly affects young children under age five, though it can occur at any age. The disease gets its name from the characteristic blisters and sores that appear on the hands, feet, and inside the mouth. According to the Centers for Disease Control and Prevention (CDC), HFMD is caused most often by coxsackievirus A16 and enterovirus 71, though other enteroviruses can also cause the condition.
Get Your Free Understanding SNAP →
The illness typically starts with a fever ranging from 101 to 104 degrees Fahrenheit, followed by mouth sores and a skin rash. Children often experience decreased appetite and difficulty swallowing due to the painful mouth sores. The rash usually appears one to two days after the fever begins. Parents frequently notice that their children are irritable, drool excessively, or refuse to eat.
HFMD spreads through person-to-person contact and is highly contagious. The virus spreads through respiratory droplets when an infected person coughs or sneezes, through direct contact with the rash or blister fluid, and through contact with contaminated surfaces or feces. The disease spreads most easily during the first week of illness. During summer and fall months in temperate climates, HFMD cases increase significantly. In tropical regions, the disease can occur year-round.
The good news is that HFMD is usually mild and resolves without treatment within seven to ten days. However, in rare cases, the virus can cause complications affecting the brain, heart, or muscles. Understanding the basics of HFMD helps parents and caregivers recognize symptoms early and take appropriate steps to manage the illness and prevent spread to others.
Practical Takeaway: HFMD is a common viral infection that causes fever, mouth sores, and a characteristic rash on hands and feet. Most cases resolve without complications within a week to ten days. Recognizing these symptoms early allows you to implement care measures and prevent the virus from spreading to vulnerable individuals.
Symptoms of hand, foot, and mouth disease typically appear three to six days after exposure to the virus. The illness usually begins with a fever between 101 and 104 degrees Fahrenheit, followed by a loss of appetite and general feeling of being unwell. Some people, particularly adults, may experience a sore throat. Within one to two days of the fever, painful sores develop inside the mouth, usually on the inner cheeks, gums, and tongue. The mouth sores start as small red spots that quickly develop into painful blisters.
Learn About Online Renewal Options by State →
The characteristic skin rash appears one to two days after the mouth sores form. The rash typically appears on the palms of the hands and soles of the feet, though it can also appear on the knees, elbows, buttocks, and genital area. The rash usually consists of small red spots that may develop into blisters. Unlike the mouth sores, the skin rash is usually not painful, though it may itch. The rash is not always present in every case of HFMD; some people may have mouth sores without a visible rash.
Contact your healthcare provider if you observe any of these situations:
In most cases, symptoms peak around days three to five and begin improving by day seven. If your child is maintaining adequate fluid intake, has no fever after day three, and is showing general improvement, HFMD is likely following its typical course. However, every child is different, and if you have concerns about your child's symptoms or how they are progressing, contact your healthcare provider for guidance.
Practical Takeaway: Learn to recognize the typical progression of HFMD symptoms—fever first, followed by mouth sores, then rash. Most cases follow a predictable seven to ten-day course. Contact your healthcare provider if fever lasts more than three days, your child cannot drink fluids due to mouth pain, or any concerning symptoms develop.
The primary goals of caring for someone with hand, foot, and mouth disease at home are to manage fever and pain while ensuring adequate hydration. Fever is the body's natural response to viral infection and typically does not require treatment unless it causes significant discomfort. However, reducing fever can help the person feel more comfortable and improve their willingness to drink fluids and eat.
Get Your Free Shein Points Redemption Guide →
Over-the-counter fever and pain reducers can help manage symptoms. Acetaminophen and ibuprofen are both commonly used options. Acetaminophen can be given every four to six hours, up to five doses in 24 hours. Ibuprofen can be given every six to eight hours, up to four doses in 24 hours. Always follow the dosage instructions on the package based on the person's weight and age. Never use aspirin in children with viral illnesses due to the risk of a serious condition called Reye's syndrome.
Since the mouth sores of HFMD are extremely painful, eating and drinking become challenging. To encourage oral intake and reduce pain:
Hydration is critically important during HFMD. Dehydration can develop quickly in young children, especially if mouth pain prevents them from drinking. Offer small, frequent sips of water, diluted juice, or electrolyte solutions. If a child refuses to drink for several hours or shows signs of dehydration—including dry lips, reduced urination, or lethargy—contact your healthcare provider immediately.
Keep the person's environment cool and comfortable. Light clothing and blankets allow the body to cool naturally during fever. Sponging with lukewarm water can provide comfort, though avoid cold water or ice, which can cause shivering and raise body temperature further.
Practical Takeaway: Manage fever with appropriate over-the-counter pain and fever reducers following package directions. Focus on providing soft, cool foods and frequent small drinks to prevent dehydration. Monitor fluid intake carefully, as reduced drinking due to mouth pain is the primary concern during HFMD.
Hand, foot, and mouth disease is highly contagious and spreads easily in settings where groups of young children gather, such as daycare centers and schools. The virus spreads through respiratory droplets from coughs and sneezes, direct contact with infected skin or blister fluid, and contact with contaminated surfaces or the stool of infected individuals. Understanding transmission routes helps you take steps to prevent spreading the virus to others.
Get Your Free Medicare and Eyewear Coverage Guide →
People with HFMD are most contagious during the first week of illness and while they have symptoms
This guide is for general information only and is not medical, financial, legal, or other professional advice. For decisions specific to your situation, consult a qualified professional. See our Editorial Policy.